ThoughtSphere Platform Release v1.18

We're excited to announce version 1.18 of the ThoughtSphere Platform – delivering a significant
application-wide modernization that creates a cleaner, more consistent user experience while
continuing to advance AI-assisted clinical data workflows.

Application-Wide Release Highlights

ENHANCED Application Modernization: The ThoughtSphere application has been refreshed
across modules to create a cleaner, more modern, and more consistent experience for end
users.

• Unified icon sets and modernized application layouts provide a more consistent visual
  experience across workflows.
• Standardized table headers and improved text wrapping make dense clinical information
  easier to read and review.
• Layout and interaction improvements reduce visual friction and make common actions easier
  to identify as users move between modules.

ENHANCED Action Management Experience:
My Actions, All Actions, and Unassigned
Actions have been refreshed to provide a more consistent and intuitive experience for managing
work across the platform.

EXPANDED Role Reassignment Controls:
Reassign actions are now available to both DM
Lead and CPM roles across applicable workflows, providing greater flexibility for managing
review ownership and workload.

ENHANCED Code Editor & Comparison Tools: The Monaco editor is now integrated with
function auto-complete and visual diff comparisons, making code development and review more
efficient across data mapping, data check creation, and ADaM & TLF generation.

ClinHUB™

Expanded Connectivity, Governance & Data Access

EXPANDED Veeva CDMS 26.1 Support: ThoughtSphere now supports Veeva CDMS 26.1
ingestion, study data source query parameters, and query writeback – helping teams maintain
connected data and query workflows as Veeva environments evolve.

NEW Batch Trial Domain Downloads: Users can now export all trail domains in a single
action, reducing repetitive download steps when working across multiple trail domains.

NEW Prompt Management: A dedicated Prompt Management interface provides a centralized
location for managing AI prompt templates used within supported workflows.

ENHANCED Clinical Mapping Workbench: The Clinical Mapping Workbench has been
modernized to provide a more streamlined mapping experience and improved consistency with
the broader platform refresh.

NEW Active-Mapping Explainability: Explainability reports are now available for active
mappings, giving users greater transparency into mapping behavior and supporting review of
mapping outcomes.

ClinDM™

AI-Assisted Data Management & Review Workflows

ENHANCED Data Checks & DM Review Experience: Data Checks and DM review workflows
have been redesigned and optimized for performance, providing a more modern and responsive
experience for configuring and reviewing checks.

EXPANDED DVP Agent & AI-Assisted Check Generation: DVP agent capabilities now
include refinement of data check logic through conversation with the agent – further enhancing
AI assistance across the data check creation workflow.

ENHANCED Synchronous Query Writeback & Zelta Integration: Real-time query writeback
is now supported, with expanded Zelta query status and response tracking to provide more
immediate visibility across query workflows.

STANDARDIZED CPT Plan Configuration: Status definitions and column layouts have been
standardized for CPT plan setup, improving consistency when configuring and reviewing plans.

ClinQ™

Centralized Review, Risk & Quality Oversight

NEW Central Data Review Suite: Listing, QTL, and medical reviews are now brought together
through unified All, My, and Unassigned review experiences – giving users a more centralized
way to find, prioritize, and manage clinical review work.
ENHANCED KRI & Risk Governance Experience: Risk Library and Promote Risks screens
now include improved column reordering, text wrapping, and UI workflows, making risk
information easier to organize and review.

A More Modern, Connected Clinical Platform

Version 1.18 represents a significant step forward in the ThoughtSphere user experience. The
application-wide modernization creates a more consistent visual language and improves
everyday usability across modules, while redesigned review experiences help users move
through complex clinical workflows with less friction.

At the same time, expanded AI-assisted planning and check generation, mapping explainability,
centralized review, and connected query workflows continue to advance ThoughtSphere as an
end-to-end clinical data orchestration platform – bringing clinical data, review, risk, and AI-
enabled workflows together in one controlled environment.

Learn More

Existing customers: contact your Customer Success Lead or
support@thoughtsphere.com discuss next steps for upgrading to version 1.18.

New to ThoughtSphere? Request a demo at sales@thoughtsphere.com
to see how ThoughtSphere is modernizing clinical data operations with connected workflows and Agentic AI.